Apigenin

Introduction

What is apigenin?

Apigenin is among the most abundant flavonoids found in a variety of fruits and vegetables, including parsley, chamomile and celery. It is also a component of red wine and beer (R).

Does apigenin get absorbed?

Apigenin is not very soluble in water. As a result, apigenin in conventional topical formulations such as ointments or tinctures penetrates the skin poorly. However, loading apigenin in ethosomes improves its skin deposition and transdermal permeation (R).

Efficacy

Show 1 more outcomes
Outcome	Grade	Effect	Evidence	Studies
Skin Elasticity	B	🠩🠩🠩 Marked	★★★ Fair	1 study 40 participants
Skin Hydration	B	🠩🠩🠩 Marked	★★★ Fair	1 study 40 participants
Skin Smoothness	B	🠩🠩🠩 Marked	★★★ Fair	1 study 40 participants
Wrinkles	B	🠫🠫🠫 Marked	★★★ Fair	1 study 40 participants
Skin Density	B	🠩🠩🠩 Marked	★★★ Fair	1 study 40 participants
Skin Barrier Function	B	🠩🠩🠩 Marked	★★★ Fair	1 study 40 participants

Mechanisms

Outcome	Grade	Effect	Evidence	Studies
Cellular Senescence	B	🠫🠫🠫 Marked	★★★ Fair	1 study 6 participants
Collagenase	B	🠫🠫🠫 Marked	★★★ Fair	1 study 6 participants
Cell Viability	D	⇧⇩ Mixed Effect	★★★ Fair	1 study 6 participants

Latest Research

What is apigenin?

Does apigenin get absorbed?

Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo (2016)